The Spring 2017 Biology Seminar Series commences with David W. Scott's talk, "Driving CARs to BARs: The road to engineered human antigen-specific regulatory and cytotoxic T cells."
The specificity of the immune system is powerful and has been harnessed in a novel therapy for cancer, called CARs (for Chimeric Antigen Receptors). Our lab has applied this approach to create regulatory police CARs that stop harmful immune responses in autoimmunity and hemophilia, and we have now driven them to BARs.